Ok here goesI had the manometry, followed by the 24 pH on the same day.You get NO DRUGS.For the manometry, they shove a thick tube up your nose and down your throat. They give you water and tell you to swallow and each time you swallow, they shove the thing further down your throat, until its in your stomach.Then you lay down and they keep having you swallow water while they look at their computer screen, and they move the tube around. Try not to swallow air, but its hard to do when your lying down with a tube in your guts.Just in case you are having the 24 hour ph test too, which often goes along with the manometry, its the same thing, except they shove a smaller tube up your nose and down your throat, and they leave it in the esophagus instead of the stomach. Since I had a lot of air and water in my stomach after the manometry, I gagged and wretched about 8 times when the thing got caught on the way down, even though this tube is actually a lot smaller. No cleanup, however, since they had me not eat the morning of the test. I felt a lot better without all that air in my stomach.I had them pull it out and we tryed it again a few minutes later without the water, and all went well.The part that sucks is having tubes shoved up your nose (it hurts), and them jamming it down your throat everytime you swallow.What also sucks is having a tube up your nose and down your esophagus for the next 24 hours. It made it hard to eat and swallow, but it didnt bother my stomach. You may want to look down while swallowing, to minimizing throat & nose pain.This thing is hooked up to an electronic device you wear around your neck with buttons to push when you have reflux, when you eat, when you go to bed, etc, so it can monitor the pH of the esophagus in different situations.Yes, its unpleasant, but not worth worrying about. It only took 10 minutes for both tests.Most people will do better than me because I am one who suffers from nausea nearly 24/7.Good luck!slacker