My headache doctor has tried me on several meds for migraine other than the normal migraine ones. One was an anti-seizure drug that worked real well, but I was allergic to an inactive part of it and had to give it up. Now I'm on Depakote, a bipolar med and my headaches are no longer worth mentioning and it doesn't affect the ibs at all either way. The dosage is WAY lower than for a person with the bipolar condition, so it doesn't affect the mental part of me.