Before I get started ï¿½.. to the respondents, a heartfelt ï¿½THANKS.ï¿½ Your responses individually, were informative, but together, were conclusive. What I mean by this is that these posts have validated my recent thoughts that MC (Microscopic Colitis) should have been equal in importance when I began to prioritize IBS. I somewhat, although not totally, shrugged of the MC because I wasnï¿½t seeing much on severe pain being associated with it (her pain is crippling at times - all too often) nor was I seeing a strong relation to the ï¿½stress-triggerï¿½ that she definitely has. I also should mention that it was a phone conversation with Shawn (Eric) a couple of weeks ago that brought focus back to MC (Thanks Shawn) which eventually led to the post to Dr. Fine and this thread.As for the gluten sensitivity, thereï¿½ve been four lab analysis where it was included. I believe three were from stool specimens and one was definitely from a biopsy. If memory serves correctly, not being 100% certain which specific test was high, the biopsy and two of the others came back in the normal range while the fourth came back one point above the high-normal line (30 being high-normal with her at 31). Because of the above normal reading on one, the Doctor prescribed a gluten-free diet, which we did. However at best it was a two week half-assed attempt in which only three days were 100% gluten free with the remainder being minimal wheat consumption and the results were zero so we shrugged the gluten idea off.Mike, Iï¿½m curious ï¿½ï¿½. Is a ï¿½standard differential dx to r/o gluten sensitivityï¿½ test a standard test that my doctor will be familiar with? Please donï¿½t tell me your firm is the only one that offers it.Barbara, ï¿½YES!!!!!!!ï¿½ My wife has suffered depression since afflicted with this illness. Sheï¿½s had a couple of really bad spells where we considered counseling and anti-depressants, but sheï¿½s got it under control in that sheï¿½ll have occasional attacks, but can pull herself out within, at the most, a day. Bad part is that after living with this always-upbeat woman for 37 years, to see her go through these bouts of depression tears my heart apart. As for the doctorï¿½s prescribed treatments:Asacol (for diarrhea) from Oct thru Feb ï¿½ Seemed a little effective in beginning, but she took herself off it in Feb and suffered no adverse effects. Hydrocod/Apap (for pain) ï¿½ This is only used as a last resort when she canï¿½t handle the pain any longer as she has always been reluctant to use pain medications. It is effective in dulling the pain when itï¿½s severe, taking it from like a 10 to an 8 or 7.Wheat-Free Diet ï¿½ Covered aboveShe also started taking Caltrate in mid April and had good results, but weï¿½re questioning now whether it was just the beginning of a ï¿½good periodï¿½ that coincided with her beginning the caltrate as sheï¿½s going through a bad period now.Once again ï¿½ï¿½. THANKS TO ALL!