I just wanted to add when I say it works on the whole condition these two things, in order to perhaps understand it more. The drugs even the newer ones mainly tartget a symptom or two, whereas HT or CBT can break the vicious cycle loop. Although they are also working on many other levels including serotonin regulation although this needs futher study in exactly how.DrugsAm J Manag Care 2001 Jul;7(8 Suppl):S261-7 Books Drug therapy options for patients with irritable bowel syndrome. Talley NJ. Existing pharmacotherapeutic options for the treatment of patients with irritable bowel syndrome (IBS) are limited in treating the multiple symptoms associated with the disorder. There is much interest in the use of serotonin agents as new therapeutics. Acting primarily through 5-HT3 and 5-HT4 receptors, serotonin elicits changes in motor function and possibly visceral sensation. Two serotonin agents were developed specifically for IBS: tegaserod, a 5-HT4 receptor partial agonist, and alosetron, a 5-HT3 receptor antagonist (which is no longer available). Phase III clinical trial data show that during a 12-week treatment period with tegaserod, IBS patients with abdominal pain and discomfort, bloating, and constipation experienced significant global relief (i.e., improvement in overall well-being, abdominal pain, and bowel habit) compared with placebo. Improvement in bowel movement frequency and consistency was achieved and pain was relieved by 1 week. During 12 weeks of treatment, alosetron was shown to elicit significant relief of abdominal pain and discomfort compared with placebo or mebeverine in female IBS patients with diarrhea. Alosetron slowed colonic transit and treatment efficacy was apparent after a week of treatment. Another 5-HT4 receptor agonist, prucalopride, which is being developed for chronic constipation, accelerates colonic transit and increases stool frequency. Therefore, this agent may be of benefit in IBS patients with constipation. PMID: 11474911 [PubMed - in process] HT and CBT2001 Aug;4(4):323-331 Related Articles, Books Psychologic Therapies for Irritable Bowel Syndrome. Boyce P. Department of Psychological Medicine, University of Sydney, Nepean Hospital, PO Box 63, Penrith, New South Wales 2751, Australia. pboyce###mail.usyd.edu.au The treatment of patients with irritable bowel syndrome (IBS) is a difficult task, as the results from therapy with pharmacologic agents have been disappointing. Psychologic treatments, in particular cognitive behavior therapy, hypnotherapy, and dynamic psychotherapy have all shown to be effective in the treatment of patients with IBS. Underpinning all these treatments is a clear understanding of a biopsychosocial model of interaction between emotion and gut function in IBS. These psychologic therapies are intended to break the negative feedback loop between emotion and gut function in order to reduce symptoms. Attention to the psychologic issues underlying IBS helps reduce psychosocial factors that maintain the presence of symptoms and inappropriate health-care seeking behavior. There are a number of common elements in the psychologic approaches that can be used in routine clinical practice; these include a detailed assessment, psychoeducation, support, and reassurance. PMID: 11469991 [PubMed - as supplied by publisher] ------------------Moderator of the
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