Hi SSS -- thanks for the thoughtful response.I have been trying really hard to find patterns and triggers. I am convinced (and my GI agreed) that a lot of it is hormonal. D is def. worse as my period approaches. Interestingly, I was almost D-free and did not take Immodium when preg. both times.Being home is generally better, but not always. Certain foods cause problems, but other times I can eat anything without an issue.Leaving home for major events is anxiety-laden and I always take 4 Immodium as a preventative. Doing my routines (food shopping, volunteering at kids' schools, things I am comfortable with, etc.) are usually ok. But again, if it's "that time of the month" or just a bad patch for an unknown reason, I will take Immodium...again.The intense anxiety comes and goes. Our son is autistic and this is a MAJOR anxiety issue for me...I worry about him constantly and watching him take his karate test, for example, sends me into a terrible downspin. I am always positive with him, but inside, I am dying, watching him struggle and be so awkward and different. I didn't sleep a wink that night and had terrible D next day -- yesteray. AH HAH! A connection??!!I didn't realize that you could take Xanax as needed. I can think of several bad episodes that I could have used real help. Times when I can't control my thoughts and just obsess and worry.Dr. feels the anxiety is contributing to all of my issues...bp, IBS, sleep and weight. I see him for a bp check in Dec. think I will discuss meds with him then.To answer one of your queries: if I didn't have IBS would I have anxiety? Yes. I know who I am...a constant worrier, a pleaser, a too-deep thinker. I cannot "shut my mind off" and I am terribly self-critical. This is certainly an interesting issue, to say the least!Thanks again for your thoughts and help. I feel that I am getting closer and closer to more relief, better relief.Water Dogs Rule!