I can relate as well. My periods with the IBS-D became so debilitating that I was out for a week every month. A combination of the Depo-Provera Birth control shot to control the periods (you don't cycle much, if at all with the shot) and taking Amitriptyline for the rest seems to have gotten all my symptoms under control. You can read more about my story in the Lotronex page under "an alternative to try", I hope you are able to find an answer as well, if nothing else you know you have support for what you and your family are contending with.I wish you health and happiness.
