Immodium is fine. But it sometimes still gives you the burn of the attack without the relief on it's way. (locks it in) I took Levsin also, but it was only good if you take it just before you eat. It only lsts about an hour. It wasn't reliable either. You could still get a D attack, but it would be a lot less. I also tried antidepressants, which did somewhat work, but not reliable either. I now take Colestid. It is a dream drug for IBD'ers. It takes away attacks and D. I take half (4 mg) the recommended dose (8mg per day) and find this to be suitable. It has changed my life. I never get attacks if I remember to take it daily. (no other side effects either) Completely safe. I am 37 and have suffered, since at least age 5. This is the only thing that has worked for me. Ask your doctor about it.