I've been on depo for a little over two years now. As with you, I am SOOO happy not have periods, because mine were severely painful as well as IBS-D aggrevating. Unfortunately, my D has not gotten better at all since being on depo. Hasn't gotten worse, but certainly isn't any better, and I actually had my first accident when I was on the shot. I've just been working harder on not eating triggering foods, and with taking calcium and that had helped me a little. too bad the shot didn't.