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The problem is NSAIDs tend to damage the lining of the GI tract so can do more harm than good. That is why people with obvious overt inflammation in the gut (like an ulcer or inflammatory bowel disease) are usually told to never take NSAIDs.Most of the "inflammation" they talk about with IBS is not the overt inflammation that you tend to take NSAIDs for anyway. There are changes in some immune cells you see with IBS, but I'm unclear if they are even in the same part of the immune system that NSAID's work on.If anything it seems antihistamines may be a more likely thing to try to take to effect the immune system. After all histamine is the chemical signal that the immune system uses to increase diarrhea to get stuff the immune system doesn't like.
 
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