I have D pretty bad. Many accidents in the pants. I don't like to take Immodium a lot because I'm afraid that it will stop working, like everything else I've tried. And because of the constipating effect of it.However, it works very successfully when taken before a stressful event, traveling, eating out (still being careful of triggers, which for me also includes overeating anything.) I feel about 99% confident with Immodium. Because it is a tiny, tiny dose of an opiate, I believe, it does calm me down a bit, too.