Thanks so much for the long post on Immodium!! this is the most info I have seenon this stuff since I started searching months ago. i too worry about taking it everyday and long term. I'm up to three a day now alternating with two aday. Nothing else seems to work and it seems to mbe the mildest drug for the purpose. My doctor says take four a day...and get out of my hair basically. Well, I'm getting out of his hair. i'm getting in a study being done on the drug alosetram for which I'll get free testing and maybe some attentin to my problem and free immodium while I'm in the study (in case I'm on the placebo or the drug doesn't work. so wish me luck!