Hi Bkrubba,Yes Allegra is a antihistamine. My gastro doctor tried to explain to me why it might work but doesn't make any sense to me. I have seen some things written about antihistamines also. I take 180 mg. in the morning. Right now, it's a prescription but I think its going over the counter. On an everyday basis, it has helped. Bentyl did nothing for me. I also took Librox and then Donnatal Extend tab (the extend part is important, I guess there's a regular Donnatal that's not as strong) I have much better luck with the Allegra then any of those. You have to give it some time though, it took about 10 days for it to kick in for me. I only kept taking it bacause I had to go back in a month and I didn't want to tell him that I had quit taking it. So I certainly did not think it was going to work. I really think it would be worth a try. However, I'm checking with my doctor now on Zofran, my insurance will pay for it if that's how its written. Most of the people who have tried it here did well didn't they? Anybody??Nanci