Hi Jim,My Gastro Doc told me that he has some patients on up to 8 a day indefinetly.If you have to take them you have to take them, what is the alternative? It is always best to take them after you have had a bowel motion, I guess they say that because it would have less to work on.You can always alternate between the Imodium and Lomotil another anti-D medication.Anyway I hope you find what helps you.Numerous people, including myself have found relief with the Caltrate Plus in the Purple and white box.Take care,Rachel