ive been suffering from ibs-d for years. although the doctors wernt sure what it was.. ive had endoscopy, colonoscopy , barium meal follow thru all results were normal. have been taking loperamide for yrs now on and off.... but have recently been back to the doctors on numerous occasions tryin to get to the bottom of this problem ... to no satisfaction... i might add...to be perfectly honest i seem to have gone full circle and im back where i first started.. at the end of my wits.Its no joke tryin to explain to the doctors that ure scared to go out incase you have an accident...4 immodium it takes just to get into the car to go to town.And as for going out for meals... well thats non existant..The doctor has now prescribed me lomotil which i have taken for the last couple of days, but its hard to tell whether its working as well as it should...I was wondering whether anyone could advise me as to how long it could take to see an improvement if any and whetther it would be safe enough to combine the lomotil and loperamide together..I would be very gratefull for any advice given at least so i dont feel like its all in my head