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In all of your explorations about what might have set this off, have you ever come up with a possible reason? (In my case, as an example, it was smoking. There are lots of other things that presumably have aided and abetted the development of it; but smoking was the first trigger.) If there can be any linkage between your first cause and inflammation--try Googling the two terms together to see what may come up--then I may have a solution for you. I have used a flavonoid (grape seed and skin, gingko biloba, bilberry, quercetin, and bromelain) combo which has anti-inflammatory uses, some of which may be specific to the colon. It is not a quick treatment--it took over a year to completely remove my D--but it has lasted for over 10 years which makes it pretty remarkable, all in all.Mark