I've just had a bad two days over Christmas, didn't eat badly or have any alcohol (!) but still had terrible diarrhoea for 2 days. Took my usual meds - 1 imodium in the morning plus 3mg of imipramine at night but it didn't seem to work.Am wondering if it's possible that after (approx) 2 years of taking imodium daily (2mg, 1 tablet) my system is now getting used to the medicine and it won't work any more? Have looked on the internet but can't seem to find out much about how long people with chronic diarrhoea have taken imodium for and whether it still works. I just hope it does or am panicking that I may be housebound again! Or perhaps I'll just have to start taking more of it each day.