Hi, I have had IBS-D for the past 10 years. Imodium has always worked. If I took 1 or 2 in the morning, I would not have to use the bathroom the rest of the day, no matter what I ate. It was something I could always count on.Lately, past 6 months or so, this is not working anymore. When I go out to dinner, 1/2 the time, I end up getting diarrhea about 2-3 hours after finishing dinner. At home, I'm fine. I usually take 1 per day on regular days, and on days I'm going out to dinner, I take 2. Saturday, I took 1 in the am as I was going shopping, and then 2 at 3pm before dinner. I ate dinner at 7pm, and granted, it was a fatty meal with Asian foods (big trigger). At 9pm, I ended up with diarrhea which was so much fun to try to explain my every 5 minute bathroom trips to my friend! Luckily, I ALSO have overactive bladder, so I blamed it on that! Anyway, I NEED to be able to count on the Imodium again. If I cut back, and take it only 1-2 times per week, will I get my tolerance level back? Or, are my symptoms just worsening and I may need more imodium? I do plan to really watch what I eat when I go out from now on. No more heavy fatty spicy meals! Before, with Imodium, I could eat whatever, and never worry. So, any suggestions? I am planning to buy some probiotics, peppermint oil capsules, and calcium and add those to my daily regimen and see if they help. I am so disheartened. I had a great routine going and felt normal again. Now, I'm back to major anxiety over going out and eating. It is very worry inducing when your "magic pill" stops working!