Hi Lisa, Acidophilus with Bifidus 6 Billion active cells really has helped me out alot, I have been on them in combination with Modulan (Canada), I take 1 Modulan and 1 Acidophilus about 15 mins.- 1/2 hour prior to eating, before each meal 3x/day.. my specialist said take them before eating, then when the food hits, it has already started to work, versus putting all the food in and then the medication...so far so good. I have only had 2 episodes(D) in the 5 months I have been on Acidophilus, definelty store the bottle in the fridge after opening as these are active good bacteria cultures. I also found my bouts of severe gas almost to the point of passing out sometimes have calmed down.Hope this helps, after all it can't hurt to try, I know I'm open to new things if it will help with my IBS. Any other suggestions on stuff you have tried please let me know.Thanks + Good Luck.