Depression does make it hard to be positive, so that is pretty normal to feel the change in dose may not help.Looks like a lot of the clinical trials do a start at 10 mgs and if that isn't enough then bump up to 20 mgs so it isn't uncommon for people to need more than the minimum dose. Hopefully that will do the trick for you. If not they may need to try another drug. Most people do find something that works but it can take a bit of experimentation to find the right drug at the right dose. It would be nice if they could predict which one a head of time, but that isn't something we can do at this time.