Information on cholchicine and prostaglandin

see http://www.aboutdigestion.com/script/main/...&ArticleKey=724 I don't think anything has been approved in either of these areas so your talking stuff in clinical trials Colchicine is pretty dangerous, see below. I know your desparate for answers but I don't know if suggesting dangerous drugs that aren't for IBS will be a useful thing to do with your doctor.

quote:SIDE EFFECTS: The most common side effects of colchicine involve the stomach and bowel and are dose related. These include nausea, vomiting, abdominal pain, and diarrhea. One of the most worrisome side effects of colchicine is that it can damage the bone marrow causing severe anemia and seriously low white blood counts, thereby increasing the risk of infections. All patients taking colchicine long-term require blood count monitoring. Colchicine can also cause hair loss, weakness, and nerve irritation

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Many of the drugs currently available that interfer with prostaglandins are things like NSAIDS which are implicated as potential causes of IBS.Here is the recent information from the Review of IBS in a recent NEJM

quote:For patients in whom constipation is the predominant manifestation of the irritable bowel syndrome, consumption of fiber may alleviate constipation and related symptoms such as abdominal pain, tenesmus, and dyschezia. [32] Constipation can also be safely treated with osmotic laxatives such as nonabsorbable carbohydrates (lactulose and sorbitol), milk of magnesia or magnesium citrate, or a polyethylene glycol solution.

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I would discuss these options with the doctor and see if he/she has any other suggestions than that.K.------------------Ph.D. in BiologyAuthorized Expert for IBS Association - Ask the Specialist forum[This message has been edited by Kathleen Mottus PhD (edited 10-22-2001).]