Len, I'm a lotronex user for a whole week in a half now. I'm a female. I find that I'm just now starting to notice the change in my bowel habits since I started taking this drug. Meaning that my D is from 4-5 times daily being reduced to maybe 2-3 and some days nothing at all. It just depends on how bad your symtoms are. Diet may have something to do with ibs, but for the most part my symtoms are mainly triggered my high amounts of stress that send me to the bathroom for hours. I do watch my diet and try to eat more healthy but did some research and ibs is mainly the mind-gut reaction. But "different strokes for different folks!" Mine is not triggered by foods but how I react to situations. But quite often after I eat I'm in the bathroom. You'll like lotronex and you'll be thanking your doc for it because now I feel like I could walk the mall with hubby and not have to worry about where's the bathroom! Hope it works for you!Brandi