In May 2000 I went into 2 1/2 months of severe depression for a reason that turned out to be non-existant. I did a number on myself and told not a soul about it. As a result the depression put me into clincal depression which itself was not diagnosed until July 2000. I went on Paxel which helped alot although it has had its own side effects. I believe during this period it was this depression and stress which kick-started my IBS. I thought a first it might have been gall bladder, liver, ulcers, etc. I had a "cadillac" version of a medical workup xrays from throat to bladder, ultra sound, urine, fecal, blood tests and I checked out healthy as a horse. My doctor said "I don't know what I'm going to do with you." I did see a gastro-intestinal specialist who felt it was IBS. This still worried me because I wondered if cancer or crone's syndrome, etc could develope--apparently not. I am, however, going to request a colonoscopy next week to be sure there is nothing else going on to help relieve the added stress of imagining terrible developments going on inside me. My pain/discomfort runs from the appendix-bladder area off and on up the right side to an area along the bottom right rib. Sometimes it feels lightly tender, or near the spot where the small and large intestine are joined there is a localized pricking sensation. Some foods seem to set it off (coffee on an empty stomach for example) I eat lots of fibre, fresh veg, fruit, bran cereals, prunes. I have periods of heart burn (reflux) and only lately a couple of days of near constipation which have passed. I'm not sure this is related but I never ever get constipated, rather the other way around. Don't let questions you have about your physical problems go unanswered by medical professionals. Be firm, demand necessary tests to pin down at least what it is not that you have. Knowing you don't have cancer or other serious disorders or disease can help reduce some of the stress. Get excersise and sleep. It all helps me.