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Eric,Thanks for posting this and the other very interesting articles that have come out in the last week or so. Not to mention thanks for having taken the time to stay on top of these things for years.It's good to see that someone still considers this topic worthy of study, especially when that someone is Dr. Camilleri. That the connection between 5-HT3 antagonists and IC has continued to baffle even the most distinguished and dedicated experts has been a source of tremendous frustration for IBS patients who would like to see wider (or for some agents, any) access to these drugs. I hope they are getting somewhere.Just FYI for anyone who is curious, this is a clinical trial studying the effects of alosetron on mucosal blood flow:http://www.clinicaltrials.gov/ct/show/NCT00370032?order=23
 
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