Lotronex was approved but then pulled by the manufacturer, it may be back. (Diarrhea predominate IBS only)Zelnorm is at the tail end of the approval process, but there are some glitches which may or may not be resolved to the FDA's satisfaction. It has been approved in Mexico and Switzerland. (Constipation predominate IBS)On a fairly regular basis some new dietary supplement for IBS comes out. Some people in hearing about one of these may think it is a new drug vs a new dietary supplement/herbal mixture.Several drugs are further back in the pipeline and may or may not be available in the next 3-10 years.K.