I don't know the answer to this for sure, but Imodium has been on the market for many years, first as a prescription-only drug and then in the over the counter version we're all familiar with. I think there would have been some publicity by now if it were associated with ischemic colitis. For what it's worth, that is not listed as a side effect in "The Nurses' Drug Handbook," But there is this caution under "Patient Teaching:" Advise patients with acute colitis to stop drug immediately if abdominal distention or other symptoms develop and notify doctor." and "tell patient to report nausea, abdominal pain or abdominal discomfort." There is also a notation that if Imodium is used for chronic diarrhea, it should be stopped if there is no improvement after taking 16 mg per day for 10 days.In my pre-Lotronex days (soon to be resumed), I used to get relief on 6 - 8 mg a day.