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This is an offshoot from the Risperdal thread: http://www.ibsgroup.org/forums/index.php?s...117816&st=0.I'm wondering if anyone has tried the supplements L-Tryptophan and P5P (form of vitamin B6) together to ease GI symptoms, anxiety, or insomnia.Here's an article about how these supplements can assist in treating these (and other) issues:http://www.smart-drugs.net/ias-tryptophan-article.htmI suffer from sleep maintenance insomnia (most nights, but not all), and also IBS-D which comes and goes, and was originally caused by SIBO (bacterial overgrowth). I'm sensitive to most traditional medications and thus try to avoid them, unless it's absolutely necessary that I take them. I'm much more open to dietary changes and supplements (although I realize that those too can cause unwanted side effects).If anyone has any expereince with this amino/vitamin combo I'd love to hear about it (positive or negative).Thanks
 

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I started taking Tryptophan about 1 1/2 years ago. My doctor prescribed it as I was having a lot of problems sleeping and with anxiety. Its helped 100% with sleeping. I used to not be able to fall asleep, I'd lie in bed for hours tossing and turning. Then once I"d fall asleep I'd wake up very often and not be able to go back to sleep again.I was constantly tired throughout the day and run down. But since I started taking the Typtophan. I sleep fine. I take it about 1 hr before bedtime and I fall asleep right away after getting into bed and I dont' wake up much unless its to go to the bathroom, but even then I go right back to sleep. I haven't noticed any improvement in my anxiety from it. Originally my doctor prescribed it to take 1-2 pills in the morning to help with the anxiety but it makes me too tired for the rest of the day. So I only take it before bed to help with sleeping. Works great!I haven't taken the B6 supplement.
 

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Discussion Starter · #5 ·
Thanks degrassi. Can I ask what dose you are using and what brand? I've read that L-tryptophan taken without B6 P5P is not absorbed as readily by the body, but in your case that seems not to be the case. Seems like it may be worth a try for my insomnia (I don't have anxiety so it not affecting that is not an issue for me). Anyway, glad to hear it works for you!
 

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Here in Canada you need a prescription for Tryptophan. My doctor prescribed it to help my sleeping. The pills are 500mg and I take 1-4 depending on how i'm feeling. Usually I take 1-2 pills but sometimes take 4 if i'm having a bad night. If you can get it over the counter, I would start with 500mg and see how that goes.
 

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Discussion Starter · #7 ·
Thanks degrassi. I think I'll go ahead and try the L-tryptophan... I may purchase one that has P5P added in (I think Lidtke makes one). I suppose the worst case scenario is that it doesn't work and I'm out about 20 dollars. I am so utterly exhausted that I feel compelled to give it a try.
 

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Discussion Starter · #10 ·
I think that if this helps my insomnia it will also help my IBS-D as a result of that. My GI symptoms are usually worse when I do not get enough sleep. Anyway, I ended up ordering Source Naturals L-Tryptophan 500mg capsules. I went with pure Tryptophan since many of the combos I was looking at had a smaller amount of T in them (300mg) and that's really what I'm going after. I usually take B supplments anyhow. I really hope this helps, even a little... Also, what's the safety profile of Tryptophan?? I read some articles about it getting banned in the 80s due to impure supply and some people actually died from that. Yeesh.
 

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Discussion Starter · #11 ·
Quick update for those who care.
I have the tryptophan, but I'm going to hold off on taking it until I talk to my GI doctor on Thursday. I stopped taking the PPI (omeprazole) I was on about 6 days ago and my sleep has improved. I have no idea whether or not insomnia could be a side effect of omeprazole (seems unlikely), or whether something else (environmental or otherwise) is going on in my life that I am unaware of that could be affecting my sleep. I have quit all froms of caffeine prior to going off the PPI though, and my sleep did not improve (and it did improve from this when I quit caffeine back in April).
 

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Quick update for those who care.
I have the tryptophan, but I'm going to hold off on taking it until I talk to my GI doctor on Thursday. I stopped taking the PPI (omeprazole) I was on about 6 days ago and my sleep has improved. I have no idea whether or not insomnia could be a side effect of omeprazole (seems unlikely), or whether something else (environmental or otherwise) is going on in my life that I am unaware of that could be affecting my sleep. I have quit all froms of caffeine prior to going off the PPI though, and my sleep did not improve (and it did improve from this when I quit caffeine back in April).
Well I care, thanks for the update and let us know what happens next.Good luck.
 

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Discussion Starter · #13 ·
The insomnia is back with a vengeance. I've been tossing and turning the second half of the night for the past 2 nights. Doctor appointment is tomorrow, although my GI doc probably won't have too much to say about insomnia. I may see if there's something he can prescribe short term just so I can get some sleep... this is killing me.
 

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faze--you totaly have my sympathies, empathies---in my experience nothing is worse than ongoing chronic insomnia. and no sleep makes all our other health problems like ibs, reflux etc worse too. our bodies and our minds must have rest.over the years i tried everything for my insomnia--all the natural stuff, cbt, sleep restriction (what a joke)then went to ambien which worked for a while then quit on me. now take 75 mg trazodone nightly for maintenance and when things get really bad and traz doesn't work i take lunesta and believe me that has been a godsend. i've been on that since it first came out in 2005 and it works wonderfully. i just take it as needed--not nightly--although i have been on it for as long as two weeks straight. and it's not a benzo, not a narcotic so it has none of the problems associated with those. no addiction, no rebound etc. the only side effect i have is a bad taste in the mouth the next morning but that tends to lessen in time and besides that as far as i'm concerned it's more than worth it. i can certainly put up with a bad taste in the mouth--with anything really--if i've had a good night's sleep. http://www.sepracor.com/products/lunesta.htmland i don't mean to sound like a pill junkie here but really--nothing else worked for me..good luck with the dr tomorrow. hopefully he'll write you a script for something.
 

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Discussion Starter · #16 ·
degrassi, no I have not tried the Tryptophan yet, although I have it. I was waiting because when I went off Prilosec the insomnia improved for a few nights, but now it's back. I'm waiting until after my doctor appt tomorrow to start taking it.annie, thanks for the info about Lunesta. I'll ask my doctor about that tomorrow. My Mom actually said it might be helpful if I got a short-term script (7-10 days) just to see if it'll "reset" my body clock or disrupt the cycle my body seems to have gotten into. Fingers crossed I'll be able to get something to help me sleep!
 

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oh yes--that's great advice from your mom--something for now just to get you back on track--like she said--reset your body clock.when i finally got my first sleep meds script--ambien--it was such an enormous relief just to know that i now actually had something that worked (at least at the time) something that i could rely on and fall back on. i then began to sleep so much better--without pills--just because of the relief in knowing they were there if i needed them.
 

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Okay, here it is:I had an appointment with my GI doc yesterday, and he took me off the omeprazole since it really didn't seem to be helping my gastritis symptoms (which are very mild anyway). I'm basically going to alter my diet and follow up with him in 6 months.I did ask him about the insomnia and prescribing something short-term to help me sleep. He didn't have a whole lot of input (being that he's a gastroenterologist), but while I was in the exam room he called a guy he knows who is a sleep specialist, and this guy basically advised against medication because, for the type of insomnia I have, once off the drugs it would cause rebound insomnia. So, there's not much else that I can do I suppose. I thought that was really nice of my doctor to consult another doctor not even in his field of expertise (he impresses me with something at every appt I've been to, but that's off topic!).Anyhow, I'm starting the tryptophan tonight and see how it goes. Degrassi, how long did you take it before you noticed it start working?Last night was awful: I had to take 2 benadryl and drink 2-3 glasses of wine to fall asleep. And it still took me three hours to get to sleep!! Argh!
 

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One tip on sleep is take a warm bath or shower about an hour before you want to go to sleep. You want it to be long enough to raise your core temp a bit as that drop in temp is a natural "time to sleep" signal and with a warm to hot shower/bath you can exaggerate it. The other harder one for a lot of people is get up the same time no matter when you went to sleep. Keeping that constant helps keep the 24 hour rhythm going as solid as possible and sleeping in because you took a long time to fall asleep the night before only makes things harder the next night.You might also want to not use any overhead lights or look at the computer for that last hour before bed. Too much artifical light can keep you in day mode rather than let you work into sleep mode. Small lamps that just light the book you are reading, etc. don't seem to be so disruptive as bright overhead lighting.
 

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Okay, here it is:I had an appointment with my GI doc yesterday, and he took me off the omeprazole since it really didn't seem to be helping my gastritis symptoms (which are very mild anyway). I'm basically going to alter my diet and follow up with him in 6 months.I did ask him about the insomnia and prescribing something short-term to help me sleep. He didn't have a whole lot of input (being that he's a gastroenterologist), but while I was in the exam room he called a guy he knows who is a sleep specialist, and this guy basically advised against medication because, for the type of insomnia I have, once off the drugs it would cause rebound insomnia. So, there's not much else that I can do I suppose. I thought that was really nice of my doctor to consult another doctor not even in his field of expertise (he impresses me with something at every appt I've been to, but that's off topic!).Anyhow, I'm starting the tryptophan tonight and see how it goes. Degrassi, how long did you take it before you noticed it start working?Last night was awful: I had to take 2 benadryl and drink 2-3 glasses of wine to fall asleep. And it still took me three hours to get to sleep!! Argh!
Low dose anti-depressants can certainly help you sleep as well as being very good for digestive system issues. Perhaps you could discuss this with your doctor.
 
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