Greetings IBS-C forum,..just a quick post.I'm participating in a study for linaclotide. It's going fairly well really. I'm sure I'm not in the placebo group. A quick summary of the drug:"..stimulation of these guanylate cyclase-C receptors increases fluid into the intestine. They report that the effects of linaclotide on rats in previous studies included increased fluid in the intestine, quicker transit time of stool moving through the intestines and reduced visceral hypersensitivity. Previous studies on humans reportedly showed that linaclotide increased transit time and improved bowel functioning without serious side effects..."This is what I've been experiencing as well. Although I find that if I take it every day, it is not as effective... Still, much much better than Amatiza!!