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I have taken Lomotil for about 1 1/2 years now. Maybe a little more. I take it about an hour and a half before I have to go out. If I am having a not so D day, I take one. If I am having D several times already or if I am going to a wedding, funeral etc I take 2. My Dr said I can take up to 6 a day. Like when my daughter was having the baby. I took 2 and about 6 hors later my stomack started feeling nervioius so I took another one. I was able to stay and await the birth without any D.Hope this helps.Take careKat