About the Immodium, you do have to be a little careful you don't get "immuned" to it. It's different for everybody but I've found that I can take it maybe 4 days a week for months and it's fine. Any more and it becomes ineffective for me, then I need to quit taking it for like a month straight. Honestly it seems like the prescription meds for the IBS-D are the ones that you get immuned to really easily.