I took Lotronex for 8 months and I had 1 bout of diarhea in the beginning, maybe two weeks after starting it. I went from having several painful bm's usually resulting in D per day to one normal painless bm per day. Diarhea and pain were gone and I ate and drank anything and everything I wanted. I went through an acquisition at my company where my husband and I both worked. He has since been laid off.I was in danger of being laid off as well. My mother passed away. We had an addition put on our house which was a debacle to say the least and throughout all of this, no attacks. Now, since I have no Lotronex, all of the pain and diarhea are back in full force. The only unpleasant side effect from Lotronex was a lot more gas, not painful though. Tom, was this what you wanted?