hi maureeni got a prescription for lotronex when itfirst came outi took two the first day and felt jittery,i slept ok that first night, but when I woke up, still lying in bed, I was still feeling jittery..since i have history of anxiety and panic attacks, I stopped taking it after only one day. I posted on here, and believe only one person said they had similar experience. I have had other drugs that gave me antagonistic effect (I think that means the opposite of what they are supposed to ), so I attribute it to that. I have no doubt at all the lotronex caused my feelings...they were very different than any others I had had inthe past. ((my doctor said lotronex could cause depression because of the serotonin blockag..well, I got anxiety) I have tried other drugs for IBS-D and never expereinced the jitters...I am not afraid to try new things.This may not help you, and you have been on it for quite a while, but this was my experience. I probably should try it again..but I am doing OK on caltrate, immodium and tranxene right now, and just don't want that awful "outside my skin" feeling I had!j