Its just not working anywhere near the way it did before! I see that many others are having the same experience...even my doctor wondered if they changed it somehow!!! If I take 1 pill per day, I do better, but due to the cost and side effects I have to take 1/2 pill and that doesn't do the trick-I still take Imodium which causes acid reflux(really terrible) and I will have awful rebound D. I can't justify taking a pill that costs nearly $6 (each) and not get the results I need, but I can't go off it for fear of the withdrawals I had before! Talk about being stuck between a rock and a hard place!!!!Does anyone else suffer headaches and dizziness and muscle aches on Lotronex?? I just needed to vent, but would also welcome any advice!!Thanks!!!