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My doctor has never mentioned Lotronex and I am seeing him next Tuesday so I thought I would bring it up to him then.I have a question though. I am IBS-D but my major issue with IBS is the pain, not the diarrhea. I am wondering if Lotronex has helped any of you with the pain aspect. I did some internet searches and some searched here on the board and it seems that Lotronex is mainly used to treat diarrhea. Thanks.