I have had IBS-D for over 20 years, infrequent at first so no diagnosis was made in the beginning. I was diagnosed with IBS two years ago by a gastroenterologist. (He ran all types of test to come to this conclusion, like Colonoscoopy, upper endoscopy, Abdominal Cat scan, abdominal ultrasound, etc) He put me on Flagyl for a month and followed up with Bentyl which did not work. I was then put on Donnatal for spasms and Darvocet as needed for pain. He recently gave me Lomotil for the diarrhea. F.Y.I. The donnatal did not seem to decrease the pain and spasms. And the Darvocet did not seem to make a difference, either. Because the last two months have been painful and difficult to the point that my social life as been placed on hold, I went back into see him. I brought in printed copies off this website for the various treatment options, and asked him about Lotronex and probiotics and their use for IBS-D? He prescribed the Lotronex and suggested that I also take the probiotics. I started the Lotronex two days ago and so far I have been burping alot with the same abdominal pain. I have not had diarrhea, so that is a good thing, but should I keep taking the Lotronex? Am I not giving it a chance to work if I quit it now? I haven't had any diarrhea the last two days, but I thought the Lotronex would help with the abdominal pain and discomfort. And it seems to feel the same if not worse. I am just feeling miserable.