I have had IBS D quite badly for about the last 5 years. I have been on anti spasmodics and nothing has helped. i recently started seeing a new GI doctor who has run some blood tests on me and I am waiting for the results and I am also finishing up a 4 week elimination diet. Basically- as long as I dont have Celiac disease he is going to put me on Lotronex. Can anyone tell me if it has worked for them and any other information that might be helpful. thanks