Does your doctor know??I ask because 1000 mgs is the max of all sources (supplement AND what you get in your diet) so you may be overdoing it a bit. I would try cutting back to 750 and see if that still works, else make sure your doctor keeps an eye on you.Since it is an osmotic laxative I suppose it depends on what you want to accomplish.If you want all the stool more evenly wettened I would think taking some with each meal would do that.If you want more of a big bolus of water to flush you out that would be more of a take all at once thing. That would be more likely to do that.K.