Hi Sarahc18!I've been taking mebeverine (colofac) for about 3 weeks now, and it does seem to be helping me. I was initially prescribed domperidone for nausea, but that made my D even worse than it already was! The colofac was then prescribed to combat the pain and D. The combination is working best for me so far, and I'm starting to work out what my trigger foods are (anyone else have a bad reaction to onions?!?). I have read some info that claims that mebeverine is no more effective at relieving IBS symptoms than is a placebo... but then, what's wrong with a placebo if it makes you feel better?Out of interest, how do you control your IBS? Is it just mebeverine, or other things too?