Has anyone had any positive experiences with medications for IBS C-type? I recently participated in a clinical trial program with a medication Novartis is testing and it changed my life. Unfortunately, the clinical trial ended and I'm back at square one. I've tried impramine and while it calmed my intestines and eliminated the swelling, it affected my thinking capacity. I felt fuzzy and light headed and couldn't do my job. I've been taking Klonopin 3 mg. for the past few years at night and it helps a bit with the spasms. I have not been able to work a full-time job for four years, but am now going through a divorce and have a job interview next week. I need to find something fast. I've heard that several pharmaceutical companies have IBS medicines in the pipeline, e.g. Pfizer has two of them which should be out within a year. Any news on any of these forthcoming drugs would be appreciated. I've made all the dietary, psychotherapy, relaxation, herbal changes that are possible. All of this has been helpful to a point, but the only thing that made my life normal was the clinical trial medicine (which they won't give any information about). Is there anything anyone has tried that has been effective for C-type?Thanks, I'm new to the group. Signed up today.