First of all I was in total disbelief when my doctor told me he thought I had IBS. Then I began to recall my mother telling me that my father suffered with stomach problems. I don't know if there is a genetic component to this disease but there must be. Second I agree that wheat sets it off something terrible, but that makes me think its Crohn's and not IBS. Also I have horrible pain, and nausea as if something is churning in my guts. I used to have flare ups regularly where I would vomit and have a bm at the same time a little trick I call burning the candle at both ends. Never any blood that I know of. I can say with 100% honesty that my condition has been mismanaged horribly. I knew I had a stomach condition but nobody told me what it was. I knew that it would flare up, and then go away. Coming with not gas so much but bloating. My stomach would bloat and there would be pain. I wouldn't want to eat because of the full feeling. I started taking Metformin and immediately started having the most severe Metformin mediated flare ups. Diarrhea, bloating, gas, and pain. The doctor finally switched me to the long acting 750mg one time a day, then I started getting used to it and it was okay for a few months. Then it started again, the pain, etc. He is very blase' about it and there have been times when I felt I needed to be in the hospital for the pain and fatigue and dehydration. But because I think anxiety is a component of all of this he refuses thinking I am "anxious" I am now off Metformin this week to allow my stomach to heal, but I told my doctor that no way will I take another Metformin the quality of my life plummeted on this medication. I would rather take Insulin to be honest. He hasn't tried any other pills. Also I tried Elavil once for the IBS and it worked, but it made my heart beat too fast. I can use it once or twice for big flare ups but not all the time.