I have taken the Levsin & the Imodium and never had headaches from them. But everyone is different.. but if you have been taking all 3 for years.. and JUST started to the headaches over the summer.. I would seriously doubt the headaches are from the meds.I would see what other things are available to help you manage the headaches if Imitrex is tough on your stomach. (Also ask the Dr if you can take something else with the Imitrex to make it easier on your gut maybe??)