HI JAN OF THE HIP....Sorry did not see your post...been elsewhere today. There are actaully more than 2 schools of thought, and this one I speak of is not a "thought" since it is a chemical process which is visible, a visiblereaction, and the function and efects of the chemicals released or formed in the reaction are already known.In simple terms, when the "circulating" immune cells or the "tissue" immune cells are triggered (appropriatley in response to pathogens or inappropriately in the form of one or more types of hypersensitivity responses) the common denominator is that the END RESULT IS THE SAME.As there are several roads to a destination, the immunologic function of the body exhibits many pathways. At the end of each, there are chemicals released from these cells that have powerful effects on the tissues of the body and on each other (sometimes new chemicals are formed or synthesized after an initial reaction).The chemicals are the chemicals of various types and degress of "inflammatory" reactions. Some are very specific ("eosinophilia can be seen for example) and some are mild and none specicif, and may not elicit much response from other cell types.So these chemical stimulate other immune cells sometimes to come to a site of action to take part in the action, they cause blood vessels to leak as the spaces between the cells open to allow free movement of celles between the intrvascular compartment and extravascular compartment, and cells from inside the blood vessel sometimes leave the blood vessel and move into the surrounding tissue, yadda yadda.Now, if you elicit a reaction within the circulatory system it does not remain localized. The chemicals are released and then circulate throughout the body. The various interfaces between blood and things outside the blood vessel (all the different tissues of the body) are to varying degrees "permeable"...sometimes their permeability is altered by the cehemicals of reaction. I simple terms some of these chemical mediators do not just sit in the plasma they move out of the plasma, and so do cells (sometimes) that contain more. So they affect any tissue or cells they come into contact with, including smooth muscle, skeletal muscle, exocrine cells, and nerve tissue. They can even move into brain tissue and nerve tissue in the spine and anywhere.This is especially problematic where unmyelinated nerves are (nerves without a myelin sheath around them). As you have read there are unmyelinated nerves in the myenteric plexus as well.The presence of certain of these chemicals can alter the apparent stimulus threshold of certain nerves, making them responsive to a lower stimulus, or respond more strongly to a given stimulus, or elecit a response spontaneously.This is why people who suffer food intolerance of an immunologic nature, or pharmacotoxic or cytotoxic reactions (all of which cause release of cytoplasm thus intracellular leukotrienes, cytokines, histamine, etc)get more than just local symptoms. The degree of severity, breadth of clinical symptoms and reaction threshold ("symptomologic sets") vary. But the bottom line is, when a granulocytic reaction occurs in the gut microvasculature in the course of an inappropriate (hypersensitivity) reaction to a food additive, chemical, or food element, the effects are often not only local but systemic as well since that blood flows OUT of the gut as fast as it flows IN, the reactions occur within the blood stream in proportion to degree of reactivity, dose and time, and the mediators are dirtibuted throughout the body up to and including the CNS. Same if an allergenic substance is absorbed directly through the buccal mucosa. A local reaction may occur, but systemic reactions as well as the "allergen" enters the bloodstream via the microvasculature.One of the reason this is so poorly understood by many people, including people of great knowledge, is very, very few people spend their time studying this. This includes most of the medical schools who rely on research for funding and vice versa, or commerical research centers. These are authorities that people who say it does not happen draw their info from. Part of it is elegantly simple based upon what makes the world go round in medicien. There is no funding for such work from the major funding sources such as drug companies.This kind of phenomenon means if you find it and avoid the cause the symptoms just go away so there is not product at the the end of theresearch work per se. Plus the technology to evaluate these phenomena have been for decades at best unreliable due to the methods employed. while there is sophistcated machinery analyzing immune reactions in seeminglt sophistcated ways, the problem is HOW they make indirect measurements and WHAT THEY ARE TRYIN TO DETECT. Simply put, analyzing and forming conclusions on the funtion of an engine by looking only at, say, the fuel system. Sometimes you get the real source of the probles and sometimes you get a RESULT of the problem, and sometimes you get a part of the mechanism of the problem. The trick is to tell which is which.However, there are a few people who have spent many years looking at these reactions and seeking ways to quantify them. technologies have been found in prior years which could show part of it, or with some degree of accuracy, but each has its weak spot.Since the ability to do that with some reasonable accuracy is so new as to be nacent, (like just a couple of years old) there has been no broad application of it as of yet. That does not mean it has not been found, nor that plenty of secondary evidence of these reactions has not been seen. Just not that many have seen it yet. This will change as it always does as time and money are expended.People have been seeing it in various forms for over 2 decades. Now, personally, I can look at it every single day if I want to at this time. Including my own. And it is nice to see it is not an illusion, and when applied clincially produces the predicted results...take away what causes this to happen, the chemicals stay where they belong inside the cells, and the symptoms casued by the chemicals subside. The trouble is it is too damsn simple for some people.That is basically a very simple way to describe an exceedingly complex set of physiologic actions.I am going to lunch now and will work to not eat anything to elicit a "granulocyte or lymphocyte response'!Have a DFDMNL_________________
www.leapallergy.com PS: I suspect the main reason the gene theory is popular is a)it is the buzz word of the times b)genomics, from a venture capital perspective, is the 'DOT COM' of the new millenium c)gene therapy is a potential "product", combined with
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and you have access to money..and you do not at this time have to prove a thing except that we DO NOT SEEM TO KNOW the etiology THEREFORE it must be genetic...BOINK...A new Business plan is born.From what has been seen in the places I get to go (on this Planet as well as Mars) the degree of genetic involvement in this is going to be that some specific sub-population is going to show a genetic predisposition to developing loss of tolerance...hypersensitivity reactions...so they will be more susceptible to the beginning of these reactions at a lower dose-time level (younger age-of-onset).Now that part is likely to prove out. But that some 43 year old person gets IBS from a genetic defect...no way Jose. But here comes another subset of "post inflammatory loss of tolerance" (post infection and antibiotics), another subset of "post NSAID overuse loss of tolerance", etc. Bottom line is there will be seen in the blood of these people granulocytes,lymphocytes,and even platelets reacting that should not react, and it does NOT FIT the tidy old fashioned classification system of GEL & Coombs.OK later...that should bring out the graphicsMNL[This message has been edited by Mike NoLomotil (edited 11-16-2000).][This message has been edited by Mike NoLomotil (edited 11-16-2000).]
S: I suspect the main reason the gene theory is popular is a)it is the buzz word of the times b)genomics, from a venture capital perspective, is the 'DOT COM' of the new millenium c)gene therapy is a potential "product", combined with
