Hi All,I have not posted in years, but I wanted to give back...My Story:I am 35 yrs old.At the age of 9 I had appendicitis and my appendix burst and was removed.Back then they did not do an appendectomy arthroscopicly, so I have a large scar where the had me open. (of course I was a small 9 yr old as well)Up to that point I was healthy with no digestive problems.This surgery or the appendix bursting triggered something. I can remember still being in the hospital, and my guts not feeling well, and running to the bathroom.From then on I had the life altering symptoms that many of us deal with.IBS-D, constant bathroom mapping, white-knuckle through almost everything, reactions to may foods and trying to find somthing I could eat that did not bother my system.Going to school everyday was a living hell. But I kept most all of it to myself, and when I did go to doctors I was passed of with "many people don't feel well" (I actually had a doctor tell me that).Between 9-10 yrs old and 33 yrs old I went to over 10 different doctors, and finally found one in Boston that did help me a bit, but still nowhere near a cure.The IBS-D has a wonderfull little friend in the form of anxiety, I had constant fear of leaving my home, and near panic attacks.Through all of this I became a reasonibly successful person. I went onto college and started my own business.People never really knew what I dealt with on a daily basis, because from the outside I not only looked well, but prosperous.Working hard and starting my business was actually part of a coping mechanism. If I kept more control, then I could handle life a bit better.But the IBS did have its toll. Mix in ADD, and it makes for much fun...Relationships were tough, and even if I was open with my problems, the psycological tolls of being trapped can wear on the best relationship...OK, now the good part:About two years ago. Living with my girlfriend in our great home with three dogs while I was napping on a lazy sunday afternoon.She wakes me to have me watch a medical show on TV. It sounds exactly like what I deal with.Some others on this site have talked about HABBA syndrome, including the medical mystery show that spoke of a woman with IBS-D symptoms after a trip overseas.I'm friendly with my GI so I dropped him an e-mail and he said its worth a try, so I tried cholestyramine (or questran, there are a bunch of names)I took it right before any decent meal....Almost instantly, over the first few days, things started to run better.Within a couple weeks, much better.A year and a half later almost perfect....One thing I would like to say is that us IBS-D's like to analyze everything, looking to the answer.What works for me is the cholestyramine and effexor for anziety.PLEASE call your doctor and try this stuff (cholestyramine)Its a simple med, and may just do wonders.I honestly belive that this may be the answer for a large percentage of the people here, and it pains me to think of another person out there suffering if they can enjoy the relief I have found.You may have HABBA, or bile acid malabsorbtion, who knows.Or this stuff may just work. The point is that after over 20 years of suffering in my own hell, I feel well.One other thing you can try.If you take an antacid, tums or rolaids along with every meal do you feel any better? (may take a few weeks)At one point over the years I found myself doing exactly that, and did feel a little better.The antacids do bind to the bile acids/salts in some way as well. (google it)That may be a way for you to see if cholestyramine may help even more.Thanks for the ear....greg