HiI'm a long time IBS D sufferer...tried many, many drugs. However, since I have been on anti-anxiety meds for almost 30 years along with all the other stuff they've tried.... any doctor I went to was not inclined to try the anti-depressant route until last year.I was on paxil for about two weeks and it didn't help my mood, my diarrhea, and made me feel just wierd is the best way I can describe it.I'm back to immodium, tranxene (anti-anxiety), calcium, and a multi vitamin. SighJeanne