I just found this board. I'm getting desperate now. I have had diagnosed IBS since 1997 and have been absolutely miserable since then. I have D type and lots and lots of abdominal pain and cramping all the time. This spell has lasted about 3 weeks now with pain to some degree all day. I was put on Lotronex but couldn't continue because it caused such constipation and discomfort. I take Imodium whenever I have to leave the house, but you just can't live on the stuff. Any suggestions?