I have pretty extreme constipation due to my crazy motility problems. I started on the Miralax not to long ago and it has helped me soooo much. Even has helped pushed gas on through. (thats a miracle for me)I started with a capful in the morning and I guess it wasn't enough because it took 6 days to start to work. My GI didn't tell me I could take 2 capfuls three times a day until my next visit to him. You can't OD on this stuff... you'll just end up with diarrhea (GI said anyway). Once I got cleaned out, I can now manage with half to 3/4 capful a day. I take it in the morning because my stomach and sm bowel are at their best then. (I struggle with vomitting due to a possible bowel obstruction) Taking the Miralax at bedtime I feel makes it easier to get on schedule by training your body to evacuate every morning. Good luck.