i've never had any biopsies or scopes or anything like that..........i relied on just how my body felt.........i personally believe that alot of medical exams can cause more damage than one would want........but i understand how u might want to just find something that would help........knowing is some peace in & of itself..........i will not tell u what i was diagnosed with last week, but i would like to know if u have any other complaints??............during the last 7yrs, i have had many complaints & problems other than the ibs-d...........they seemed unrelated to the ibs..........the operative word being "seemed"..........i've had exhaustion, skin rashes that come & go, never seeming to b the same, body aches, throwing up, nausea, bloating, intestinal pain & churning, migraines, altho not too many lately, mind fog & some others i can't think of right now.........so what r u dealing with, even if u don't think about them much cause the ibs-d is so over-whelming??..........it can seem that this thing is just so life changing.............it does impinge on everything in ur life, but let me tell u, there r worse things.........the fact that u have ibs-d, is ur body' way of telling u there is something wrong, something not working right..........sometimes it's ur body' way of trying to get rid of something, something that maybe it can't get rid of.........i have been treated for candida over-growth for 2yrs & it has caused me alot of misery & it is a horrible thing to deal with, it also does cause D.........do u have sinus trouble or allergies??........there r so many things that it might mean........how old r u??.........as we age we don't make as much serotonin as when we r young & this can cause D, too...........have u tried tryptophan & or 5HTP?..........i did get some relief from those..........they stop spasms in the intestines, which can cause D.........u have to take them w/niacin, B2, P5P, chelated magnesium & a little bit of vitamin C.........those make a big difference.........there r so many things that might make a difference..........i have always found that listening to my body is the best thing to do, which can b a hard thing to do........would u answer my questions, i would like to know about u.........i may b able to help..........