Hello, I’ve been lurking here reading the stories for the last couple years after being diagnosed with PI-IBS 3 ½ years ago. I was very healthy- then at 35 during a stressful period I got a severe stomach flu about 4 years ago-sick in bed for a week and a half, vomiting up everything even water. Went to the hospital during in the sickness, told it was stomach flu so I should just let it run its course. About a week later, feeling better but diarrhea continued though I was having no pain whatsoever. After a couple months of consistent D, I went to see another doctor who told me I had mild IBS and that it should clear up in a couple months. Sure enough things seemed to clear for a few weeks then later that fall the d returned and continued regularly. Did the usual- after the Dia first thing in the morning took a couple immodium then was locked up for the rest of the day and often the next, then the cycle would continue. After 6 months decided my job stress might be causing the problems so I quit and got a very mellow and fun job. During this time I saw a new doctor who prescribed Florastor probiotic. The day after taking it I had a semi formed movement for the first time in months. I continued on with the Floristor and Immodium for a year or so with more predictable (though unsatisfying) movements. The doctor also prescribed Lorazepam at this time which helped during stressful periods. I was managing but would have these uncomfortable urges or sensations in the bowel from time to time though nothing was there and occasionally huge amounts of dia for no apparent reason. Had a consult with a Gastro doc who gave me a colonoscopy which apart from one small polyp was all clear. Felt great after the cleanout prior to the colonoscopy, but that didn’t last. About a 6 months later I got really sick again, this time with prostatitis. I was given Cipro for this and it cleared up quickly. I also noticed my bowel movements seemed better until a few months later when I had another hugely stressful financial crisis when things got worse. Had a stool test for C-diff but came back negative. At this point I retooled my career and started working from home. I worked on removing stress from my life, listened to the IBS Audio 100 program, eventually went to a hypnotherapist and worked on talking therapy. Things leveled off but were still annoying and interfering with my day to day activities. I noticed during this time that after a bowel movement the gut and bowel started to feel sore and uneasy and I was getting the occasional twinge in the urethra often after urinating. Also, the feeling of incomplete evacuation an hour or so after a movement. Saw a new Osteopathic/Naturopathic doctor who listened very carefully to my history and then concluded I had some sort of underlying infection or dysbiosis in the gut. I started taking Nystatin for a Candida infection for 4 months during which time I laid off the Immodium and eliminated carbs or anything else that could feed the yeast. At the 3 month mark I was still having very soft loose stools and for the first time, a really upset stomach. I went back to the doc who stopped the Nystatin, then prescribed Xifaxan for bacterial infection. No changes. Then Low Dose Naltrexone for inflammation. During the first week I had bouts of very sore stomach and once was woken up with huge stabbing pain in the abdomen behind the belly button. -Later that morning, really bad Diarrhea. After this the doctor was convinced there is still some underlying infection so he prescribed Flagyl which seemed to do nothing. I have kept a log of my diet, bm’s and any symptoms/sensations for the last 8 months. The doctor feels there is no food intolerance and my symptoms truly seem to be random. (though it is true that acute stress makes the symptoms worse). It seems to be a cycle of one day bad Dia, then a reasonably good day, then 2 or 3 days of progressively worse bm’s and the cycle starts all over again. I apologize for the huge post, or if I posted in the wrong spot and I realize that so many people here have much worse symptoms than me and I truly sympathize . It’s so crazy that there isn’t more research being done to get to the bottom of this. Any thoughts anyone may have would be greatly appreciated.