I've done a good bit or research on Immodium and there do not seem to be any long term side affects from it. It seems to be safe to take even 4 a day..some folks here take many more than that even. A few have said they have developed a tolerance for it but only after many years on high doses. i've been taking it for 7 months now and I seem to be needing less instead of more but like last night I had a bad attack and have taken four in the last 24 hours. It sure does get things under control in a hurry for me. I don;t know what I would do without it since nothing else seems to do much for my problem.I would always be open to trying other things but not worry about taking the Immodium. It really does not seem to harm you.