My new gastroenterologist has changed me from a 25mg tablet of Amytriptaline per day, to the liquid form (generic) which I had never heard of before. I take 3-4 drops in water, 3 times a day and have noticed I now have formed stools for the first time in years. I still take calcium and Immodium as usual. But there is still not much difference in the "I need to go - NOW" problem. He sent me for blood and stool tests and they all came back negative, so I am down for an endoscopy and colonoscopy at the end of June - ugh! The prep in France now is to go on a very strict diet ('non-residue' it is called), which seems to consist of mainly eating rice and pasta and drinking just water for 5 days prior to the test, then to drink 2 small bottles of a prep liquid 12 hours apart to clean you out. I am so thankful I don't have to take the huge bottle of nasty liquid I had to drink in the past! Wish me luck! I am not too hopeful there will be any other diagnosis but IBS at the end of all this, but maybe he will be able to sort me out. At least they will check for everything whilst I am under the anaesthetic! Wish me luck?