Hi Linda:Working is a really tough issue for those of us with severe IBS. Unfortunately, there aren't any miracle medications that definitely work for everyone. Some people get relief from dietary changes alone. There is a woman who posts frequently about her success with calcium supplementation. Some people find relief through hypnosis, relaxation, yoga, meditation, etc. Some others find that certain types of medications can be helpful. Some of these include the anticholinergic/antispasmodics which include Bentyl, Levsin, Librax (which also contains a mild tranquilizer), Levbid, etc. Other medications fall into the antidepressant category with strong anticholinergic effects such as Elavil and Pamelor. Other antidepressant medications called SSRIs help some IBS sufferers who mainly suffer IBS with anxiety and/or depression. These include Paxil, Zoloft, and Prozac. All drugs have side effects, however, and sometimes these can be quite difficult to live with. Do you have a good gastroenterologist who is able to work with you on your problem?I hope this information helps you a little and I'm glad you found this board. It is really helpful to be able to share experiences with other people who know what you are going through.Good luck. ~JR~